Stephen V Liu, Director of Thoracic Oncology, Chief of the Division of Hematology and Oncology, and Associate Professor at Georgetown Lombardi Comprehensive Cancer Center, shared a post on X about a paper by Monique B. Nilsson et al. published in the Journal of Thoracic Oncology:
“More on resistance to ADCs in the Journal of Thoracic Oncology. Studies of T-DXd (HER2 ADC) suggest a wide range of mechanisms, including payload resistance (via SLFN11 loss and copy number gains of ABCC1/MRP1 efflux pump) and HER2 extracellular mutations, not just antigen loss.”
Title: Loss of payload sensitivity and other mechanisms of resistance to T-DXd in HER2-mutant NSCLC: implications for subsequent responsiveness to HER2 TKIs
Authors: Monique B. Nilsson, Xiuning Le, Alissa Poteete, Xiaoxing Yu, Junqin He, Qian Huang, Yuji Shibata, Ximeng Liu, Cesar Moran, Ash A. Alizadeh, Maximilian Diehn, Heather Wakelee, Diego Almanza, Scott Soltys, Takeshi Sugio, Jurik Mutter, Xiaoman Kang, Rui Wang, Soyeong Jun, Mohammad Shahrokh Esfahani, Hai Tran, Yuanxin Xi, Lingzhi Hong, Xiaofang Huo, Ashwani Kumar, Xiaoyang Ren, Kei Oguchi, Kazuhisa Minamiguchi, Caroline M. Weipert, Jing Wang, Ralf Kittler, and John V. Heymach
You can read the Full Article in the Journal of Thoracic Oncology.
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