Sanam Loghavi, Associate Professor of Pathology at MD Anderson Cancer Center, Medical Director of ECOG-ACRIN Leukemia Bank and Editor in Chief of Image Bank at the American Society of Hematology, shared a post on LinkedIn:
”Our myeloid sarcoma paper out today…
Free to download until tonight thanks to AACR Journals. We hope you enjoy reading it.
Some key highlights (but read the paper):
- Myeloid sarcoma (MS) essentially always originates in the BM and then homes to extramedullary tissues, even when BM is morphologically ‘normal’
- MS evolves through a ‘Darwinian’ molecular evolution with acquisition of additional hits compared to medullary AML
- MS is underdiagnosed … ctDNA (cell free DNA) is very good at picking up MS, we believe it has great potential as a surveillance tool for MS
- RAS pathway activation (with or without RASp mutations) is a cardinal feature of MS and represents a therapeutic vulnerability
- MS adapts to the tissue microenvironment through upregulation of EMT (epithelial meaenchymal transition) programs and remodels the tissue immune micro environment.”
Title: RAS pathway activation and microenvironmental adaptation as hallmarks of myeloid sarcoma
Authors: Bettina Nadorp, Audrey Lasry, Sanam Loghavi, Ravi Patel, Hager Mansour, Pier Edoardo Rovatti, Benjamin J. Kelly, Christopher J. Walker, Jill Buss, Isaiah Boateng, Wafa Al-Santli, Zoe Ciantra, Rebecca Austin, Helee Desai, Hasan Abaza, Linda Procell, Tejas Patel, Bejamin Kaffenberger, Saranga Wijeratne, Maria Guillamot, Maria Velegraki, Luis A. Chiriboga, Zihai Li, Daniel A. Pollyea, Christine M. McMahon, Arwa Shanaah, John C. Byrd, Manel Esteller, Eirini P. Papapetrou, Aristotelis Tsirigos, Alice S. Mims, Elaine R. Mardis, Iannis Aifantis, Ann-Kathrin Eisfeld
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