Rupam Manna, Medical Oncologist, Entrepreneur, interested in Metabolism education and brain science, shared a post on LinkedIn:
“MMR or MSI? One of the most common areas of confusion in oncology and pathology.
A simple way to remember it:
MMR = Machinery (IHC)
MSI = Mistakes (PCR/NGS)
- IHC checks whether the DNA mismatch repair proteins (MLH1, PMS2, MSH2, MSH6) are present.
- PCR/NGS measures the genomic consequence – microsatellite instability.
High-yield takeaway:
- dMMR ≈ MSI-H
- pMMR ≈ MSS
- MSI-L is uncommon and is generally managed similarly to MSS for most clinical decisions, including immunotherapy selection in colorectal cancer.
Save this visual for exam revision and daily oncology practice.”
Other articles about DNA on OncoDaily.
