Ron DePinho, Professor of Department of Cancer Biology, Division of Discovery Science at MD Anderson Cancer Center, shared a post on LinkedIn:
“Simona Colla is an extraordinarily talented scientist focused on MDS at UT MD Anderson.
I’d like to draw attention to her landmark study in Cancer Cell by Cell Press linked telomere dysfunction directly to aberrant hematopoietic differentiation and myelodysplastic syndrome. Her work provided genetic evidence that aging-associated telomere erosion can reshape progenitor fate, disrupt RNA splicing programs, and drive MDS-like disease.
These insights provided an important bridge between aging biology and hematologic malignancy.”
Title: Telomere dysfunction drives aberrant hematopoietic differentiation and Myelodysplastic Syndrome
Authors: Simona Colla, Derrick Sek Tong Ong, Yamini Ogoti, Matteo Marchesini, Nipun A Mistry, Karen Clise-Dwyer, Sonny A Ang, Paola Storti, Andrea Viale, Nicola Giuliani, Kathryn Ruisaard, Irene Ganan Gomez, Christopher A Bristow, Marcos Estecio, David C Weksberg, Yan Wing Ho, Baoli Hu, Giannicola Genovese, Piergiorgio Pettazzoni, Asha S Multani, Shan Jiang, Sujun Hua, Michael C Ryan, Alessandro Carugo, Luigi Nezi, Yue Wei, Hui Yang, Marianna D’Anca, Li Zhang, Sarah Gaddis, Ting Gong, James W Horner, Timothy P Heffernan, Philip Jones, Laurence JN Cooper, Han Liang, Hagop Kantarjian, Y Alan Wang, Lynda Chin, Carlos Bueso-Ramos, Guillermo Garcia-Manero, Ronald A DePinho
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