Rishabh Jain, Medical Oncologist at AIIMS, shared a post on X:
“PFS win. OS flat.
HER2CLIMB-02 updated results at ESMO Breast 2026.
HER2+ MBC | n=463
Brain mets included.
PFS:
- 9.5 vs 7.4 mo
- HR 0.74 – positive
CNS PFS:
- 7.8 vs 5.7 mo
- HR 0.74 – positive
OS:
- 43.3 vs 41.0 mo
- HR 0.98 – negative
Tucatinib and T-DM1 improves PFS, not OS.
Still relevant for CNS disease?”
