Noelia Tarazona, Research Fellow at Mass General Brigham Cancer Center, shared on LinkedIn about a paper she co-authored with colleagues published in ESMO Open:
“Our latest study in head and neck cancer is now published in ESMO Open.
Using whole-exome ctDNA sequencing, we explored how tumors evolve from diagnosis to relapse in locally advanced HNSCC.
Key insights:
- ctDNA uncovers ITH often missed by single-site biopsies
- Clear clonal shifts arise at relapse, reflecting treatment-driven evolution
- Relapsed disease shows enrichment of RHO GTPase and IL-6/JAK/STAT3 pathways
- Several actionable alterations emerge, pointing to potential targeted therapies
- ctDNA proves valuable for tracking tumor dynamics over time.”
Title: Whole-exome ctDNA sequencing reveals intratumoral heterogeneity and drivers of relapse in locally advanced head and neck cancer
Authors: G. Bruixola, J. Martín-Arana, F. Gimeno-Valiente, J.A. Carbonell-Asins, B. García-Micó, B. Martínez-Castedo, D. González-Camblor, N. Grimalt, M. García-Bartolomé, C. Alfaro-Cervelló, V. Escorihuela, M.E. Iglesias, M. Maroñas, D. Dualde, A. Cervantes, N. Tarazona
You can read the full article in ESMO Open.
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