Nicholas Navin, Director, Advanced Spatial Genomics Core, Professor and Chair, Department of Systems Biology, Director, CPRIT Single Cell Genomics Center, Associate Professor at UT MD Anderson shared a post on LinkedIn:
”We are excited to share our new pan-cancer study of cancer evolution, which included 7 major cancer types and was published in Cancer Discovery.
This study was led by Hanghui Ye and the team in my lab UT MD Anderson and was a wonderful collaboration with Thomas McDonald and Franziska Michor at Harvard University.
We used nanowell scDNA-seq to analyze 94 human tumors across 7 major cancer types (bladder, breast, colon, glioblastoma, kidney, lung, and ovarian) together with bulk exome sequencing, which showed that most solid tumors evolve from a single cancer cell and that subclonal diversity is associated with CNA burden, TP53 mutations and increased geographic diversity in tissues.
Many tumors evolve through punctuated bursts of evolution at the earliest stages of progression, extending our initial work in breast cancer.”
Title: A pan-cancer single-cell analysis of intratumoral copy number diversity and evolution
Authors: Hanghui Ye, Thomas O. McDonald, Reem Elghaish, Emi Sei, Darlan Conterno Minussi, Min Hu, Shanshan Bai, Chenling Tang, Junke Wang, Kaile Wang, Robert J. Downey, Anna Casasent, Michael D. Nicholson, Hui Chen, Franziska Michor, Nicholas E. Navin
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