Robert Orlowski, Deputy Chair of Lymphoma/Myeloma, Vice Chair of MM Research, and Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared a post on X:
“Myeloma Paper of the Day:
RRM2-driven trafficking is a novel and targetable mechanism of antigen escape in CAR-T; osalmid may restore MICA/B presentation and potentiates NKG2D CAR-T cell efficacy and could potentially enhance CAR-Ts across many antigens.”
Title: Targeting endosomal trafficking-mediated antigen escape to resensitize myeloma to CAR-T therapy
Authors: Zhuning Wang, Guanli Wang, Yujie Liu, Yufei Zhao, Shushan Guo, Yicun Yang, Qikai Zhang, Chaolu Hu, Shuaikang Chang, Xiaosong Wu, Dong An, Huifang Hu, Haiyan Cai, Li Zhang, Jumei Shi
You can read the Full Article in Journal for ImmunoTherapy of Cancer.
You can find other articles featuring Robert Z. Orlowski on OncoDaily.
