Ibrahim Halil Sahin, Associate Professor of Medicine at the University of Michigan Medical School, shared a post on LinkedIn about a recent article he and his colleagues co-authored, adding:
“Our study investigating molecular features of liver and non-liver metastasis of MSS CRC is now published.
Proud of my mentees Drs Tara Magge and Svea Cheng who led this work.
Some interesting findings :
- In our study we observed shorter time on frontline chemotherapy among patients presenting with liver metastasis of MSS CRC, indicating the liver metastasis may be also linked to chemotherapy resistance similar to what we see with immunotherapy
- Our study also suggests that liver and non-liver metastases of MSS CRC carry relatively similar molecular characteristics with similar frequencies of well known driver oncogenes
- Lack of distinct molecular characteristics between liver and non liver metastasis of MSS CRC, points to the tumor microenvironment of the liver which is likely the the underlying reason for treatment resistances we observe in our clinical practice
- An interesting finding from our study, although our study showed similar rates of common driver oncogene such as BRAF and KRAS, their impact at each metastatic site appears to be different.
- Our study is the first to show BRAF v600e predominantly prognostics for patients without liver metastasis while this was limited for those presenting with liver metastasis! The opposite interaction was noted for KRAS mutation
Highly interesting findings in our study, warranting larger studies to validate our findings.”
Title: A Comparative Study of Clinical and Molecular Features of Microsatellite Stable Colorectal Cancer With and Without Liver Metastases
Authors: Tara Magge, Svea Cheng, Shuaichao Wang, Masood Pasha Syed, Bhaghyasree Jambunathan, Ashley Mcfarquhar, Paola Zinser Peniche, Doga Kahramangil Baytar, Aatur Singhi, Anwaar Saeed, Ibrahim Halil Sahin
Read the Full Article on Cancers
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