Frank Weinberg, Assistant Professor at University of Illinois Hospital and Health Sciences System shared a post on LinkedIn:
“Excited to share our latest work published in Cancer Prevention Research exploring how the lung microbiome may influence lung cancer biology.
In this study, our team performed integrative multi-omic analysis (microbiome, metabolomics, and cytokines) from bronchoalveolar samples of patients with early-stage lung cancer. Truly a labor of love to get this important research initiated, performed, analyzed and published!
We found that tumor-affected lung lobes show enrichment of specific bacteria and fatty acid metabolites, including stearic acid, which can reprogram macrophage inflammatory signaling.
These microbial–immunometabolic interactions may contribute to early lung tumorigenesis.
Importantly, this work identifies a potential fatty acid–macrophage axis that could serve as a biomarker for early detection and prevention strategies in high-risk individuals undergoing lung cancer screening.”
Title: Integrative Analysis of Multiomic Pathways Predicts Cancer-Affected Lobes in Lung Cancer
Authors: Frank Weinberg, Abhinav Achreja, Amrita Roy, Olamide Animasahun, Baharan Meghdadi, Anjali Mittal, Fei Yang, Martin Davis, Kathy M. De La Torre, Osama Mohamed, Shari L. Barnett, Aradhana Mohan, Srinadh Choppara, Gurcharan Kaur, Alicia Hulbert, Samuel E. Weinberg, Robert P. Dickson, Ashootosh Tripathi, Rishindra M. Reddy, Nithya Ramnath, Deepak Nagrath
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