Emil Lou, Professor with Tenure at University of Minnesota, shared a post on LinkedIn:
“Fresh off of AACR26, and in the lead-up to ASCO26, hot off the press here in Cell Reports Medicine by Cell Press led by the University of Minnesota team and the lab of Dr. Rong Stephanie Huang, University of Minnesota College of Pharmacy:
Sex-biased intratumoral microbiome influences tumor molecular and immune landscape and disease outcomes.
This work is at the nexus of studies on the influence of microbiome on carcinogenesis and efficacy of immunotherapy, sex-based differences in cancer biology, long-range intercellular signaling, and so much more.
This paper is a tour de force led by Dr. Yuting Shan, who successfully defended her Ph.D in recent weeks (congratulations, Yuting!) and whose work was supported by a Translational Research Development Program (TRDP) award through our NIH-supported UMN CTSI. The TRDP aims to provide an opportunity for early stage investigators to gain significant experience with clinical and translational research; I had the pleasure of serving as a translational co-mentor for Yuting on this project, and she has already launched follow-up projects that will shed light on early-onset colorectalcancer and more.
Direct link to the published manuscript, now online in Cell Reports Medicine.
Highlights:
- Sex difference in intratumoral microbiome is evaluated in >5,000 tumors
- Reproducible sex-differential microbial taxa have been identified
- Male- and female-biased taxa show opposite link to estrogen and interferon pathway
- Sex-differential taxa alter cell response to drugs and patient survival.
Congratulations and thanks to all authors: Yuting Shan, Yingbo Huang, Adam Lee, Radwa Elmorsi, Tuyen Phan,Indrajit Chaudhury, Thomas Corbiere, from Caris Life Sciences, Lindsey B Collins, Elizabeth Hirsch, Jennifer Johnson, Jefferson Health, Emmanuel S. Antonarakis, Masonic Cancer Center, University of Minnesota, Emil Lou, Rong Stephanie Huang.”
Other articles featuring Emil Lou on OncoDaily.