Daisuke Kotani, GI Medical Oncologist, Chief Physician at the Department of Gastrointestinal Oncology at the National Cancer Center Hospital East, Japan, shared a post on X:
“Immunotherapy and Targeted Therapy for Gastroesophageal Cancer: ASCO Guideline Update
Adenocarcinoma
HER2-postive
- CPS ≥1: Pembro + Trastuzumab + Chemo
- CPS <1: Tras + Chemo
HER2-negative
- CPS ≥1 and CLDN(-): ICI + Chemo
- CPS <1 and CLDN(+): Zolbe + Chemo
- CPS ≥1 and CLDN(+): ICI or Zolbe + Chemo
- CPS <1 and CLDN(-): Chemo alone
SCC
- CPS ≥1: ICI + Chemo or Nivo + Ipi
- CPS <1: Chemo alone
Visualizing estimated rate of death per 1,000 patients with GEA by CPS(see photo in the Gallery).”
Title: Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline Update
Authors: Manish Shah, Erin Kennedy, Dana Deighton, Minaxi Jhawer, Kunal Kadakia, Sarbajit Mukherjee, Christopher Nevala-Plagemann, Anwaar Saeed, Bryan Schneider, Thomas Semrad, Kohei Shitara, Laura Tenner, Nataliya Uboha, Melani Vincelli, Davit Zohrabyan, Lakshmi Rajdev
Read the Full Article.

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