Daisuke Kotani, GI Medical oncologist, Chief physician at Department of Gastrointestinal Oncology at National Cancer Center Hospital East, Japan, shared a post on XÂ about a recent article by Takashi Akiyoshi et al, adding:
“Longitudinal ctDNA analysis in rectal cancer treated with TNT
ctDNA clearance at restaging: 100% in 25 patients with cCR or near cCR vs 51% in 39 with non-cCR
Non-clearance of ctDNA = surgery, but clearance ≠NOM”
Title: ctDNA Longitudinal Analysis during Total Neoadjuvant Therapy and Nonoperative Management for Locally Advanced Rectal Cancer: A Biomarker Study from the NOMINATE Trial
Authors: Takashi Akiyoshi, Eiji Shinozaki, Yusuke Maeda, Senzo Taguchi, Akiko Chino, Yutaka Hanaoka, Shigeo Toda, Shuichiro Matoba, Antony Tin, Erik Spickard, Tetsuro Tominaga, Kohei Shigeta, Koji Okabayashi, Shimpei Matsui, Toshiki Mukai, Tomohiro Yamaguchi, Hiroki Osumi, Adham Jurdi, Minetta C. Liu, Naoki Miyazaki, Kensei Yamaguchi
Read the Full Article on Clinical Cancer Research
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