Cristiane Bergerot, Head of the Department of Psycho-Oncology at Grupo Oncoclínicas, Brazil, posted on X:
“We can treat painful neuropathy, but can we prevent it?
This trial shows duloxetine (30 or 60 mg) did not reduce OIPN vs placebo.
Back to the drawing board.”
Title: Alliance A221805: Duloxetine to Prevent Oxaliplatin-Induced Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Phase II Study
Authors: Ellen M. Lavoie Smith, Minji Lee, Mary R. Scott, Heshan Liu, Shauna Hillman, Tracy Rieken, Rachel Wills, Julian Diaz-Cobo, Selina Chow, Heidi D. Finnes, Kathryn Ruddy, Jeffrey Meyerhardt, Eileen O’Reilly, Tareq Al Baghdadi, Narjust Florez, Jordan Kharofa, Rang Govindarajan, Mohamedtaki Tejani, Ki Chung, David Zahrieh, Charles Loprinzi, Maryam Lustberg

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