Angela Mastronuzzi, Head of Neuro-Oncology Unit at Bambino Gesù Children’s Hospital and President of AIEOP, shared a post on LinkedIn about an article she co-authored with colleagues published in Oxford Academic’s Neuro-Oncology:
“Just published by Oxford University Press on behalf of the Society for Neuro-Oncology:
‘A Systematic Study of Molecular Diagnosis, Treatment and Prognosis in Infant-Type Hemispheric Glioma): An Individual Patient Data Meta-analysis of 164 patients‘
Due to the novelty and rarity of infant-type hemispheric glioma (IHG), optimal treatment and factors determining clinical outcomes are yet to be established. We curated a series of 164 patients with IHG; 155 identified by methodical literature search and nine additional patients contributed by collaborators.
Our findings show that IHG is a fusion driven tumor of the very young that is survivable even after progression. While optimal primary therapy for patients with IHG has yet to be established, the findings of this meta-analysis suggest treatment should focus on lowering surgical morbidity and improving its success.
The authors would like to acknowledge the patients and their family for giving their authorization to research.
We would also like to thank Dr. Arzu Onar-Thomas, Member, Department of Biostatistics, St. Jude Children’s Research Hospital – ALSAC for reviewing the statistical analysis and providing guidance, and Dr. Soniya Pinto for her help and contribution with diagnostic imaging illustrations.”
Title: A Systematic Study of Molecular Diagnosis, Treatment and Prognosis in Infant-Type Hemispheric Glioma): An Individual Patient Data Meta-analysis of 164 patients
Authors: Lara Chavaz, Aditi Bagchi, Sandeep K Dhanda, Fabienne Toutain, Stefan M Pfister, Dominik Sturm, Torsten Pietsch, Gerrit H Gielen, Andreas Waha, Matthew Clarke, Congyu Lu, Michael Karremann, Martin Benesch, Thomas Perwein, Gunther Nussbaumer, Christof Kramm, Maura Massimino, Veronica Biassoni, Maria Vinci, Angela Mastronuzzi, Dannis van Vuurden, Sophie E M Veldhuijzen van Zanten, Alan Mackay, Chris Jones, David T W Jones, Ana S Guerreiro Stucklin, Uri Tabori, Cynthia Hawkins, Scott Ryall, Andrés Morales La Madrid, Alvaro Lassaletta, Simon Bailey, Darren Hargrave, Jason Chiang, Moatasem El-Ayadi, Bruna Minniti Mançano, Rui Manuel Reis, Christian Hagel, Hamza Gorsi, Nicolas Silvestrini, Ahmed Gilani, Ludmilla Papusha, Paul Klimo Jr., Xin Zhou, Amar Gajjar, Giles W Robinson, Andre O von Bueren
You can read the full article in Oxford Academic’s Neuro-Oncology.
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