Akhil Kapoor, Professor of Medical Oncology at Tata Memorial Centre, shared a post on LinkedIn:
“Our New publication in JCO Oncology Advances.
Our systematic review evaluates the methodological landscape of microbiome testing in lung cancer, focusing on sequencing-based approaches and metabolomic profiling.
Key highlights:
- Systematic review of 87 human lung cancer studies (2014–2023)
- 16S rRNA sequencing remains the dominant approach (86%)
- Shotgun metagenomics offers deeper taxonomic and functional insights but remains underutilized
- Short-chain fatty acid (SCFA) profiling provides a functional bridge between the gut microbiome and systemic immune modulation
- Significant methodological heterogeneity exists in DNA extraction, sequencing platforms, targeted 16S regions, and bioinformatic pipelines
The review emphasizes an urgent need for standardization of microbiome methodologies to enable reproducibility and facilitate translation of microbiome biomarkers into clinical oncology.
Microbiome profiling holds promise for improving treatment response prediction, immune modulation strategies, and personalized oncology approaches in lung cancer.”
Title: Translational Implications of Microbiome Testing Methodologies in Lung Cancer: A Systematic Review of 16S rRNA Sequencing, Shotgun Metagenomics, and Short-Chain Fatty Acid Profiling
Authors: Akhil Kapoor, Anuj Gupta, Bipinesh Sansar, Bal Krishna Mishra, Gopalakrishna Kallapura, Prashanth Giridhar, Rohit Kumar.
Read the full article here.
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