Ajay Major and Andrew Evens
Ajay Major and Andrew Evens/X

Ajay Major: Peripheral IV vs Central Venous Catheter for First Line Anthracycline Therapy

Ajay Major, Founder and President of Pager Publications and Assistant Professor of Medicine at the University of Colorado School of Medicine, shared a post on X:

“PIV vs CVC 1L anthracycline chemo –

  • 1414 patients: 50% CVC (79% port, 22% PICC) – extravasation: 1 CVC, 2 PIV
  • No difference in induration, phlebitis, VTE, erythema between CVC and PIV
  • However, more pain/tenderness and infiltration with PIV

Which centers use PIV for R-CHOP/ABVD?”

Andrew Evens, Deputy Director for Clinical Services at Rutgers Cancer Institute, shared this post, adding:

“>1,400 lymphoma patients and >9,300 anthracycline treatment infusions (with ABVD or CHOP) were examined (~50% each peripheral IV [PIV] and central port/PICC): there was 1 confirmed case of extravasation (1 of 4363 [0.02%] infusions) for patients treated via PIV.

Altogether, use of PIV is safe and effective for lymphoma pts treated with anthracycline-based regimens.

Kudos to Yun Kyoung Ryu for leading this large multicenter project and analysis.”

More posts from ASH 2025.