Insight

Aug 15, 2025, 12:51

Castalia Fernández: Promising for Neuroprotection

Castalia Fernández, Radiation Oncology Specialist at GenesisCare, shared on X about a recent paper by Vinai Gondi et al. published on JCO:

“NRG-CC003 trial: Hippocampal avoidance (HA) during prophylactic cranial irradiation (PCI) in small cell lung cancer (SCLC) didn’t meet primary endpoint for 6-month Hopkins Verbal Learning Test-Revised (HVLT-R) Delayed Recall preservation (30.0% vs 25.5% deterioration, p=0.28), but noninferior 12-month intracranial relapse (ICR; 14.8% vs 14.7%), reduced overall neurocognitive function (NCF) failure risk (hazard ratio/HR 0.78, p=0.039), no diff in overall survival (OS)/toxicity. Promising for neuroprotection! ”

Title: Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003

Authors: Vinai Gondi, Stephanie L. Pugh, Minesh P. Mehta, Jeffrey S. Wefel, Wolfgang A. Tomé, Alexander Y. Sun, John Grecula, Kristin J. Redmond, Shannon Fogh, Laurie Gaspar, Andre Konski, Joseph Bovi, Clifford G. Robinson, Benjamin Corn, Gregory M. Videtic, Benjamin H. Lok, Harold A. Yoon, John H. Heinzerling, Albert S. DeNittis, Ronald C. McGarry, Kiran Devisetty, Vijayananda Kundapur, Abraham J. Wu, Edward C. McCarron, Isabelle Thibault, Edmund L. Simon, Andrew M. Baschnagel, Samir Narayan, Jondavid Pollock, Rebecca Paulus, Lisa A. Kachnic

Read the full article.

Castalia Fernández

Giuseppe Minniti, Radiation Oncologist at Sapienza University of Rome, shared Castalia Fernández’s on X:

“Much more than just HA is necessary for preservation of neurocognition in patients receiving brain RT. Ongoing research is focusing on all limbic system, cingulate gyrus, precentral areas, and white matter tracts, among others.”

Other posts featuring Castalia Fernández.

Abraham J Wu Albert S. DeNittis Alexander Y. Sun Andre Konski Andrew M. Baschnagel Benjamin Corn Benjamin H. Lok brain RT Clifford G. Robinson Edmund L. Simon Edward C. McCarron GenesisCare Giuseppe Minniti Gregory M. Videtic Harold A. Yoon ICR Isabelle Thibault Jeffrey S. Wefel John Grecula John H. Heinzerling Jondavid Pollock Joseph Bovi Kiran Devisetty Kristin J. Redmond Laurie Gaspar Lisa A. Kachnic Lung cancer Minesh P Mehta NCF Rebecca Paulus Ronald C. McGarry Samir Narayan SCLC Shannon Fogh Stephanie L. Pugh Vijayananda Kundapur Vinai Gondi Wolfgang A. Tomé

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