E. John Wherry: What’s the Difference Between Trm and Exhausted CD8 T cells?
E. John Wherry, Director at Institute for Immunology and Immune Health, shared a post on X he and colleagues co-authored published in bioRxiv.
“What’s the difference between Trm and exhausted CD8 T cells?
Simone Park’s new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses.”
Title: Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential
Authors: Simone L. Park, Mark M. Painter, Sasikanth Manne, Victor Alcalde, Maura McLaughlin, Matthew A. Sullivan, Divij Mathew, Leonel Torres, Yinghui J. Huang, David B. Reeg, Naomi R. Douek, Trenton Campos, Max Klapholz, Maria A. Cardenas, Victoria Fang, Shin Foong Ngiow, KC Wumesh, Rishi R. Goel, Amy E. Baxter, Jennifer E. Wu, Melody Tan, Corbett T. Berry, Christoph T. Ellebrecht, Alexander C. Huang, Emily Papazian, Ying Liu, Karthik Rajasekaran, Robert M. Brody, Erica R. Thaler, Devraj Basu, Ahmed Diab, Josephine R. Giles, E. John Wherry
Read The Full Article at bioRxiv.
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