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Sylvester Comprehensive Cancer Center Researchers Uncover Molecular Drivers of Cellular Differentiation

Sylvester Comprehensive Cancer Center/X

Aug 13, 2025, 05:14

Sylvester Comprehensive Cancer Center Researchers Uncover Molecular Drivers of Cellular Differentiation

Sylvester Comprehensive Cancer Center shared a post on LinkedIn:

“In two published papers, researchers at Sylvester documented their use of a new RNA sequencing technology to identify molecular drivers of cellular differentiation, paving the way for improved regenerative therapies. Beyond its lab applications, this technique, Rapid Precision Run-On Sequencing (rPRO-seq), could also help doctors understand patients’ disease states and responses to treatment in real time.

Both papers were published in Molecular Cell (Cell Press) – the first on July 24 and the second on August 7.

This research resulted from a multidisciplinary collaboration led by Dr. Ramin Shiekhattar, with contributions from:

Lluis Morey, Ph.D., Sylvester researcher and associate professor in the Dr. John T. Macdonald Foundation Department of Human Genetics
Danny Reinberg, Ph.D., Sylvester researcher and distinguished professor in the Dr. John T. Macdonald Department of Human Genetics
Daniel Bilbao, Ph.D., M.B.A., director of the cancer modeling shared resource at Sylvester and associate professor of pathology and laboratory medicine at the University of Miami Miller School of Medicine
Xiangxi Xu, Ph.D., professor of radiation oncology at the Miller School, who worked on the preclinical models
Derek Dykxhoorn, Ph.D., professor in the Dr. John T. Macdonald Foundation Department of Human Genetics
Colleagues at Northwestern University

Learn how the team is using this leading-edge RNA sequencing technology to uncover the molecular drivers behind cellular differentiation, which could lead to better regenerative therapies.”

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cancer Daniel Bilbao Danny Reinberg Derek Dykxhoorn Lluis Morey Molecular Cell Northwestern University OncoDaily Oncology Ramin Shiekhattar Rapid Precision Run-On Sequencing rPRO-seq Sylvester Comprehensive Cancer Center Xiangxi Xu

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