Koichi Takahashi: How Does Cancer Chemotherapy Drive the Evolution of Therapy-Related Myeloid Neoplasms?
Koichi Takahashi, Physician Scientist at MD Anderson. Researching and treating leukemia, shared on X:
“New paper in Nature Genetics!
How does cancer chemotherapy reshape the HSC landscape and drive the evolution of therapy-related myeloid neoplasms? We uncovered this process through single-colony WGS! See the full paper here!
This work appears back-to-back with a powerful study from Jyoti Nangalia and Mike Stratton (Wellcome Sanger Institute) profiling the impact of wide array of cytotoxic therapy on human hematopoiesis.
Also, accompanied by a fantastic editorial by Terrance Wong and Dan Link, placing our findings in the broader context of CH and t-MN evolution.
Together, our studies offer complementary views into how chemotherapy leaves genetic damage to our normal HSCs, remodels the stem cell architecture, and drives therapy-induced malignancies.
Big thanks to our many collaborators Peggy Goodell, Elizabeth Shpall, Chiraag Kapadia, Jyoti Nangalia, Mike Spencer Chapman, Daisuke Nakada Drs. Haeno/Saeki Tokyo University of Science (TUS)
Huge congratulations to all members of the Takahashi Lab – especially our superstar computational scientist/physician-scientist, Hidetaka Uryu, who truly did it all in this project! and Ken Furudate, ClonalHematopoiesis, tMN, SingleCell, TP53, PPM1D.
And nothing delights you more than seeing your work highlighted by Eric Topol”
Title: Clonal evolution of hematopoietic stem cells after autologous stem cell transplantation
Authors: Hidetaka Uryu, Koichi Saeki, Hiroshi Haeno, Chiraag Deepak Kapadia, Ken Furudate, Jyoti Nangalia, Michael Spencer Chapman, Li Zhao, Joanne I. Hsu, Chong Zhao, Shujuan Chen, Tomoyuki Tanaka, Zongrui Li, Satoko Ogata, Sarah Hanache, Hui Yang, Courtney DiNardo, Naval Daver, Naveen Pemmaraju, Nitin Jain, Farhad Ravandi, Jianhua Zhang, Xingzhi Song, Erika Thompson, Hongli Tang, Latasha Little, Curtis Gumbs, Robert Z. Orlowski, Muzaffar Qazilbash, Kapil Bhalla, Simona Colla, Hagop Kantarjian, Rashmi Kanagal-Shamanna, Carlos Bueso-Ramos, Daisuke Nakada, Gheath Al-Atrash, Jeffery Molldrem, P. Andrew Futreal, Elizabeth Shpall, Margaret Goodell, Guillermo Garcia-Manero and Koichi Takahashi
An insightful article about cancer chemotherapy.
-
Challenging the Status Quo in Colorectal Cancer 2024
December 6-8, 2024
-
ESMO 2024 Congress
September 13-17, 2024
-
ASCO Annual Meeting
May 30 - June 4, 2024
-
Yvonne Award 2024
May 31, 2024
-
OncoThon 2024, Online
Feb. 15, 2024
-
Global Summit on War & Cancer 2023, Online
Dec. 14-16, 2023