Mara Antonoff: Study Links High cNLR to High tNLR and Pro-Tumor Microenvironment
Mara Antonoff, Associate Professor of Thoracic and Cardiovascular Surgery at MD Anderson Cancer Center, shared a post on X about a paper she co-authored with colleagues published in the Journal for ImmunoTherapy of Cancer:
“This Kyle Mitchell study shows high circulating neutrophil-to-lymphocytes (cNLR) reflects high tumor NLR (tNLR), high tNLR is associated with immunosuppressive/pro-tumor TME, and tNLR is a stronger negative prognosticator than cNLR in resectable NSCLC.”
Title: Intratumoral neutrophil-to-lymphocyte ratio is mirrored by circulating neutrophil-to-lymphocyte ratio in non-small cell lung cancer
Authors: Kyle G. Mitchell, Younghee Lee, Nathaniel Deboever, Marcelo V. Negrao, Hai T. Tran, Edwin Parra, Lauren Byers, Alexandre Reuben, Lorenzo Federico, Chantale Bernatchez, Jing Wang, Mara B. Antonoff, Ara A. Vaporciyan, Stephen G. Swisher, Tina Cascone, Ignacio I. Wistuba, John V. Heymach, Don L. Gibbons, Jianjun Zhang, Daniel J. McGrail, Boris Sepesi, Cara L. Haymaker.
You can read the Full Article in the Journal for ImmunoTherapy of Cancer.
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