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Galip Can Uyar: The Phase 3 CONTACT-02 Trial
Jul 2, 2025, 09:11

Galip Can Uyar: The Phase 3 CONTACT-02 Trial

Galip Can Uyar, Medical Doctor at Etlik City Hospital, shared a post on X about a paper by Neeraj Agarwal et al. published in The Lancet Oncology:

“BREAKING in mCRPC
Published in The Lancet Oncology (July 2025)
The phase 3 CONTACT-02 trial shows:
Cabozantinib + Atezolizumab significantly improves PFS over second ARPI (6.3 vs 4.2 months; HR: 0.65, p=0.0007)
But no OS benefit was observed (14.8 vs 15.0 months; HR: 0.89)
ORR: 13% vs 6%, DCR: 72% vs 53%
A novel AR-independent combo, especially promising for patients with poor prognosis extrapelvic soft tissue metastases.”

Title: Cabozantinib plus atezolizumab in metastatic prostate cancer (CONTACT-02): final analyses from a phase 3, open-label, randomised trial

Authors: Neeraj Agarwal, Arun A Azad, Joan Carles, Nobuaki Matsubara, Stéphane Oudard, Fred Saad, Axel S Merseburger, Andrey Soares, Bradley A McGregor, Bogdan Zurawski, Marinos Tsiatas, Scott North, Igor Bondarenko, Margarita Alfie, Evangelos Bournakis, Lorenzo Antonuzzo, Lena Evilevitch, Andrew Simmons, Fong Wang, Roberta Ferraldeschi, Prachi Nandoskar, Sumanta K Pal.

You can read the Full Article in The Lancet Oncology.

Galip Can Uyar: The Phase 3 CONTACT-02 Trial

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