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Tuğba Başoğlu: A New Chapter for ADCs in EGFR+ NSCLC Begins
Jun 25, 2025, 07:56

Tuğba Başoğlu: A New Chapter for ADCs in EGFR+ NSCLC Begins

Tuğba Başoğlu, Associate Professor at Kartal Dr. Lutfi Kirdar City Hospital, shared Oncology Brothers’s post on X:

“FDA approval alert!

Dato-DXd has been approved for previously treated EGFR-mutant NSCLC based on pooled data from tropionlung 01 and 05.

  • ORR: 43%
  • mDOR: 7.0 mo
  • mPFS: 5.8 mo
  • mOS: 15.6 mo

A new chapter for ADCs in EGFR+ NSCLC begins.”

Quoting Oncology Brothers’s post:

“Datopotamab deruxtecan (DatoDXd – Trop2 ADC) now FDA Oncology approved off TROPION Lung 01 and 05 for previously treated mEGFR NSCLC

  • ORR of 42.7%, mDoR 7.0 mos
  • mPFS: 5.8 mos and mOS 15.6 mos
  • AEs: Nausea, stomatitis, and ILD”

An interesting article about NSCLC.