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Goutham Sunny on KRAS G12C inhibition in non-small cell lung cancer
Goutham Sunny/X
May 21, 2025, 18:05

Goutham Sunny on KRAS G12C inhibition in non-small cell lung cancer

Goutham Sunny, Resident Doctor at The Gujarat Cancer and Research Institute, shared a post on X:

“KRAS G12C in NSCLC review
KRAS G12C-mutant NSCLC (~14%) has seen progress with sotorasib/adagrasib, but resistance, brain mets, and co-mutations (STK11/KEAP1) limit outcomes.
Sotorasib/adagrasib offer benefit, but future lies in ON-state/pan-RAS/tricomplex inhibitors and rational combos (ICIs, SHP2, SOS1, chemo). Next-gen strategies aim to boost efficacy, overcome resistance and tackle CNS disease—tolerability will be crucial. 
How quantum computing has been helping to design KRAS inhibitors”

Goutham Sunny

Title: Dealing with KRAS G12C inhibition in non-small cell lung cancer (NSCLC) – biology, clinical results and future directions

Journal: Cancer Treatment Reviews

Authors: Ilaria Attili, Carla Corvaja, Pamela Trillo Aliaga, Ester Del Signore, Gianluca Spitaleri, Antonio Passaro, Filippo de Marinis

Read the full article.

Goutham Sunny

Title: Quantum biological convergence: quantum computing accelerates KRAS inhibitor design

Journal: Signal Transduction and Targeted Therapy

Authors: Taeho Kwon, Hakjin Kim

Read the full article.

Goutham Sunny

More posts featuring Goutham Sunny on OncoDaily.

Adagrasib Antonio Passaro cancer Carla Corvaja Ester Del Signore Filippo de Marinis Gianluca Spitaleri Goutham Sunny Gujarat Cancer and Research Institute Hakjin Kim Ilaria Attili KRAS G12C non small cell lung cancer NSCLC OncoDaily Oncology Pamela Trillo Aliaga Sotorasib Taeho Kwon
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