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Case of The Month #40 – PSOGI
May 13, 2025, 07:56

Case of The Month #40 – PSOGI

PSOGI(Peritoneal Surface Oncology Group International) shared a post on LinkedIn:

“PSOGICASE
CASE OF THE MONTH #40

Summarized here

Management of symptomatic, MSI-H colorectal peritoneal metastases
With Paul Sugarbaker and Peter Cashin

Evidence is evolving in favour of non-surgical treatment of MSI-H tumors. But do we have all the answers yet 

  • Are there any indications for surgery in MSI-H CPM
  • What drug (s) to be used and when?
  • Immunotherapy for symptomatic patients 
  • Response assessment- when, how 
  • Management of progression on immunotherapy 

We are the happiest when medical oncologists evesdrop on the dicussion.
Thanks Pashtoon Kasi for your inputs.

Mandatory reading

Circulating tumor DNA (ctDNA) serial analysis during progression on PD-1 blockade and later CTLA-4 rescue in patients with mismatch repair deficient metastatic colorectal cancer

Authors: Pashtoon Murtaza Kasi, Griffin Budde, Michael Krainock, Vasily N Aushev, Allyson Koyen Malashevich, Meenakshi Malhotra, Perry Olshan, Paul R Billings and Alexey Aleshin

Case of The Month #40 - PSOGICase of The Month #40 - PSOGI