Sendurai Mani: 7th most cited research article published in Cell
Sendurai Mani, Professor of Medicine specializing in Cancer Biology at Brown University, shared a article by Wafik S. El-Deiry on LinkedIn:
“Reflecting on my PhD student days, I remember how everyone was talking about a paper published in the Journal Cell.
It wasn’t just another publication; it was a groundbreaking study that brought to light the importance of a vital gene called p21/WAF1 in cancer biology, showcasing its essential role down the line from the tumor suppressor gene p53.
Even now, it holds an impressive rank as the 7th most cited research article (with an astounding 16,575 citations) published in Cell since the journal’s inception in 1974.
The surprising twist is that the first author who discovered this WAF1 gene, Dr. Wafik S. El-Deiry, MD, PhD, FACP, is the director of the Legorreta Cancer Center at Brown University and was instrumental in my move to Brown University—a huge congratulations to Dr. El-Deiry on this huge achievement.”
Wafik S. El-Deiry, Associate Dean for Oncologic Sciences at the Warren Alpert Medical School and Director of the Legorreta Cancer Center at Brown University, shared this post on LinkedIn, adding:
“Thanks Mani. It was the number one most highly cited original research paper in Cell for >20 years.”
Title: WAF1, a potential mediator of p53 tumor suppression
Authors: Wafik S. El-Deiry, Takashi Tokino, Victor E. Velculescu, Daniel B. Levy, Ramon Parsons, Jeffrey M. Trent, David Lin, W.Edward Mercer, Kenneth W. Kinzler and Bert Vogelstein
Sendurai A. Mani is an Indian-American oncologist and molecular biologist. Currently holding the Dean’s Chair for Translational Oncology at Brown University Warren Alpert Medical School, Dr. Mani also serves as the Associate Director for Translational Oncology at the Legorreta Cancer Center at Alpert Medical School. Dr. Mani’s research focuses on finding the mechanisms driving cancer metastasis and therapy resistance, particularly in breast cancer. He is renowned for his discovery of cancer stem cells and their role in tumor progression and treatment resistance.
Wafik S. El-Deiry, MD, PhD, FACP, FRSM, is the Associate Dean for Oncologic Sciences at the Warren Alpert Medical School and Director of the Legorreta Cancer Center at Brown University and Director of the Joint Program in Cancer Biology at Brown University and affiliated hospitals. He is the Editor in Chief at Oncotarget. Dr. El-Deiry discovered p21(WAF1) as a p53 target gene, cell cycle inhibitor, and tumor suppressor that explained the mammalian cell stress response. Dr. El-Deiry’s research is focused on mechanisms of therapy resistance with major efforts in drug discovery and development.
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