Sourat Darabi Highlights Whole Exome vs Transcriptome Sequencing in Melanoma and Thyroid Cancers
Sourat Darabi, Director, Precision Medicine and High-Risk Intercept Programs at Hoag Hospital, shared a post on LinkedIn about a paper published on International Journal of Molecular Sciences:
“We conducted a retrospective analysis comparing whole exome and transcriptome sequencing in melanoma and thyroid cancers. To assess MAPK pathway activity, we calculated a MAPK Activation Score (MPAS) using normalized expression values across ten MAPK-associated genes.”
Title: BRAF V600E Mutation Has Variable Tumor-Specific Effects on Expression of MAPK Pathway Genes That Could Affect Patient Outcome
Authors: Sourat Darabi, Phillip Stafford, David R. Braxton, Carlos E. Zuazo, Taylor J. Brodie, Michael J. Demeure
Read the full article.
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