Raffaele Colombo: Here the breakdown of the Monomethyl auristatin E Antibody Drug Conjugates

Raffaele Colombo, Principal Scientist at Zymeworks, shared on X/Twitter:

106 auristatin Antibody Drug Conjugates (ADCs) have reached clinic development, of which two-thirds (= 71 ADC) with Monomethyl auristatin E (MMAE) as payload! Here the breakdown of the MMAE ADCs:  

• 4 approved by FDA
•  1 approved by the National Medical Products Administration in China
• 41 in clinical development  
• 25 discontinued

The MMAE history:

Source: Raffaele Colombo/Twitter