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Risk stratification of individuals with a germline CDKN2A pathogenic variant
Nov 12, 2024, 12:57

Risk stratification of individuals with a germline CDKN2A pathogenic variant

Lumír Kunovský, shared a post by Sara Nikolić, GI fellow at UKC Maribor, on X, adding:

“November is Pancreatic cancer awarness month. Risk stratification of individuals with a germline CDKN2A pathogenic variant

Thanks for sharing Sara.

What’s New.

1 in 4 individuals with a germline CDKN2A pathogenic variant are expected to develop pancreatic cancer in their lifetime

Only in UEGJ.

Risk stratification of individuals with a germline CDKN2A pathogenic variant

Cumulative incidence of pancreatic ductal adenocarcinoma (PDAC; red) or death from other causes (blue).

 

Only in UEGJ.”

 Risk stratification

Quoting Sara Nikolić‘s post:

“Despite surveillance in carriers of a mutation CDKN2A, late stage and interval pancreatic cancer still occur

High risk:

– 1st-degree Pregnancy with PDAC
– Smoke history

Current model not reliable for clinical practice. Biomarkers.”

 Risk stratification

Pancreatic cancer surveillance: Risk stratification of individuals with a germline CDKN2A pathogenic variant

Authors: Derk C. F. Klatte, Jihane Meziani, Djuna L. Cahen, Merel van Diepen, Marco J. Bruno, Monique E. van Leerdam, the Dutch Pancreatic Cancer Surveillance Group

 Risk stratification