Anirban Maitra: Do multiple tumor promoting pathways converge on a common family of kinases?

Anirban Maitra shared on X:

“Provocative Cancer Discovery paper from Nabeel Bardeesy, Mass General Cancer Center et al.

Do multiple tumor promoting pathways – LKB1 loss, PRKACA fusion, and GNAS mutation – all converge on a common family of kinases (SIK kinases)?

Implications for variants of Pancreatic Cancer (GNAS mutant or LKB1 null IPMNs, DNAJB1-PRKACA fusion positive IOPNs).
Beautiful study!

DNAJB1-PRKACA fusion drives fibrolamellar liver cancer through impaired SIK signaling and CRTC2/p300-mediated transcriptional reprogramming.”

Source: Anirban Maitra/X

Dr. Anirban Maitra serves as Professor of Pathology and Translational Molecular Pathology at UT MD Anderson Cancer Center since August 2013, and directs the Sheikh Ahmed Pancreatic Cancer Research Center. He leads an NCI-funded laboratory dedicated to pancreatic cancer research, focusing on genetics and molecular pathology in human and mouse models. His research aims to advance early detection and interception strategies to enhance patient survival rates in pancreatic cancer.