Changing the Future of Adolescent and Young Adult Cancer Care

Adolescent and Young Adult Cancer Care is critical for AYAs with cancer, a unique and vulnerable population aged 15 to 39 years. Globally, approximately three billion AYAs reside in low- and middle-income countries (LMICs), yet their cancer outcomes are significantly underreported and under-researched. Resource limitations in LMICs exacerbate challenges in the diagnosis, treatment, and survivorship care for this group. The study “Care of AYAs with Cancer in Low-Resourced Countries” aims to address these disparities by identifying barriers and proposing solutions to improve Adolescent and Young Adult Cancer Care outcomes in these settings.

Call for Participation

We invite all healthcare professionals involved in the care of adolescents and young adults (AYAs) with cancer to contribute to a crucial initiative aimed at enhancing cancer care for this unique population. Your expertise and insights are invaluable in shaping the future of AYA oncology.

Join the SIOP movement for better AYA cancer care!

Importance of the Study

This study seeks to systematically assess the barriers faced by AYAs with cancer in LMICs. By gathering data on existing practices and gaps through global collaboration, the study aims to:

• Develop resource-adapted guidelines for AYA oncology care.
• Advocate for age-specific training programs for healthcare professionals.
• Identify innovative strategies to improve access to timely diagnosis and treatment.

Global AYA Cancer Crisis: 89,500 Diagnoses, Thousands Lost

Adolescents and young adults (AYAs) with cancer face unique challenges, worsened in low- and middle-income countries (LMICs) by systemic barriers. Survival rates for AYAs in LMICs are significantly lower than in high-income countries (HICs). For instance, five-year survival for acute lymphoblastic leukemia (ALL) in LMICs is 39%-63%, compared to over 80% in HICs. Breast cancer survival in LMICs ranges from 60%-85%, while osteosarcoma survival is 47%-83%. Krista Ariello JCO Glob Oncol. 2025

The cancer burden among AYAs is substantial. In 2020, the U.S. saw 89,500 new AYA cancer cases and 9,270 deaths, with LMICs expected to have even higher burdens due to late diagnosis and limited treatment. Some cancers, like thyroid cancer, are rising 3%–4% annually, yet many LMICs lack proper diagnostic and treatment infrastructure. Kimberly D Miller CA Cancer J Clin 2020

Exclusion from clinical trials further limits AYA access to novel therapies, particularly in LMICs with weaker research infrastructure. Psychosocial support services, including mental health care, fertility preservation, and survivorship programs, are also scarce.These disparities highlight the need for targeted interventions and global collaboration to improve AYA cancer care, focusing on better diagnosis, specialized treatments, and comprehensive support systems.

You Can Also Watch Empowering Conversations During AYA Awareness Week by OncoDaily

During AYA Awareness Week in 2024, OncoDaily, in collaboration with the AYA Working Group of SIOP, hosted a discussion with Dr.Ruzanna Papyan Dr. Gabriela Villanueva, Ruzanna Papyan, and cancer survivor Carmen Monge. The conversation focused on key challenges in cancer care and survivorship for young adults.

Dr. Ruzanna Papyan, a pediatric oncologist, emphasized the unique challenges faced by young adult cancer patients, particularly the emotional and psychological aspects of survivorship. She advocated for a more integrated approach to care that recognizes the specific needs of this demographic, including mental health support, fertility preservation, and help with reintegrating into normal life. Dr. Papyan also spoke about her work with the AYA Working Group of SIOP, which aims to improve care for young adult survivors. She stressed the importance of global collaboration to ensure these patients have access to specialized care.

Carmen Monge, cancer survivor and advocate, shared her journey and introduced her book series, “Can-Can and the Adventure on Ming Island,” aimed at teaching children about cancer through diverse characters. Together, Dr. Papyan and her colleagues highlighted the need for inclusive, comprehensive care for young adult cancer survivors, focusing on both medical and emotional needs.

You Can Also Read Ruzanna Papyan: SIOP Global Health Network AYA Working Group, Charlas de Café by OncoDaily and SIOP

Psychological and Emotional Support in Adolescent and Young Adult Cancer Care

Adolescents and young adults (AYAs) with cancer face unique psychological challenges, as cancer disrupts critical developmental milestones like forming relationships, pursuing education, and gaining independence. Tailored support systems that include counseling, therapy, peer connections, and psychosocial interventions are essential.

Cancer triggers a wide range of emotions in AYAs, from fear and sadness to anxiety. These emotions evolve throughout the cancer journey, often shifting from shock to determination. Long-term emotional distress, such as PTSD, depression, or concerns about recurrence, is also common.

Psychosocial support helps AYAs cope with the emotional toll of cancer. Counseling and therapy address anxiety, depression, body image concerns, and relationship dynamics. Family therapy supports AYAs and their loved ones through relational challenges. Peer support groups, both in-person and online, connect AYAs facing similar experiences, while art therapy offers creative outlets to process emotions.

Breaking Barriers in Adolescent and Young Adult Cancer Care

The disparities facing AYAs with cancer in low-resourced settings demand urgent attention. With survival rates significantly lower than those in HICs and limited access to specialized care, a collaborative effort is essential. By participating in this study, healthcare professionals can contribute valuable insights that will help bridge gaps and improve outcomes for AYAs worldwide. Together, we can drive meaningful change and ensure that all young people with cancer receive the care they deserve—regardless of geographic or economic barriers.