Yüksel Ürün: Ivonescimab Delivers Significant Overall Survival Benefit in NSCLC
Yüksel Ürün/LinkedIn

Yüksel Ürün: Ivonescimab Delivers Significant Overall Survival Benefit in NSCLC

Yüksel Ürün, Professor of Medical Oncology at Ankara University School of Medicine, shared an update from Summit Therapeutics, on X, adding:

Ivonescimab beat pembrolizumab on overall survival in first-line PD-L1+ NSCLC!

Next chapter is longer follow-up from the separate global HARMONi study, including Western patients. Different trial. Different population. But critical for understanding geographic translatability.”

Quoting Summit Therapeutics:

Ivonescimab Monotherapy Demonstrates a Statistically Significant and Clinically Meaningful Benefit Compared to Pembrolizumab Monotherapy in PD-L1-Positive Advanced NSCLC in Akeso’s HARMONi-2 Study Conducted in China

Ivonescimab Reduced the Risk of Death by 27% Compared to Pembrolizumab.

PD-L1 High Expression Subgroup: Hazard Ratio = 0.58.”

This also can be interesting:

HARMONi-6 Trial at ASCO Plenary 2026: Ivonescimab Plus Chemotherapy Improves Overall Survival in Advanced Squamous Non-Small Cell Lung Cancer

Yüksel Ürün: Ivonescimab Delivers Significant Overall Survival Benefit in NSCLC