Yüksel Ürün, Professor of Medical Oncology at Ankara University, shared on X:
“Can non-tumor-specific T cells destroy cancer?
A new study shows activating bystander T cells inside tumors can kill cancer cells via paracrine signaling. Could this expand immunotherapy options?”
Title: Intratumoral T cell activation kills tumors regardless of T cell specificity
Authors: Olivia C. Ghirardelli Smith, Tyler T. Dao, Noah V. Gavil, Stephen D. O’Flanagan, Adam J. Rubin, Son Nguyen, Matthew B. Watowich, Nuo Liu, Eyob Weyu, Clare F. Quarnstrom, Andrew G. Soerens, Vineet Joag, Pamela C. Rosato, Matthew F. Krummel, Melissa A. Geller, Jeffrey S. Miller, Alessio Giubellino, Vaiva Vezys, Alex K. Shalek, David Masopust