Thomas Ichim, President and Chief Scientific Officer at Immorta Bio, shared on X:
“Why is the oral baking soda not neutralized by the stomach acid?
In a triple-negative breast cancer mouse model, oral bicarbonate enhanced anti-PD-L1 treatment, increasing tumor T-cell infiltration and expression of IFN-gamma, IL-2 and IL-12p40.
Tumor acidity may be a surprisingly powerful regulator of immunity.”
Title: Immunotherapy Enhancement by Targeting Extracellular Tumor pH in Triple-Negative Breast Cancer Mouse Model
Authors: Azizur Rahman, Branislava Janic, Tasnim Rahman, Harshit Singh, Haythem Ali, Ramandeep Rattan, Mohsin Kazi, Meser M Ali
You can also read:
- OptiTROP-Breast01 Final Analysis: Sacituzumab Tirumotecan Sustains Overall Survival Benefit in Previously Treated Metastatic Triple-Negative Breast Cancer
- Neoadjuvant SBRT and Immunotherapy Show Potential in High-Risk ER+/HER2− Breast Cancer
- Datopotamab Deruxtecan Approved in China for Advanced Triple-Negative Breast Cancer
