Sarah Sammons, Co-Director Breast Cancer Research and Treatment Program at University of Maryland Medical System, shared on X:
“TROPION-Breast02 brain metastases analysis at ESMO26 (Dent). 1L Dato-DXd vs chemo, mTNBC, n=61 with BMs:
- CNS PFS 9.5 vs 2.6 mo, HR 0.27,
- icORR (measurable) 62.5% vs 37.5%,
- Untreated BMs: OS HR 0.35,
- Longest icDoR ~27 mo.
Preferred Trop2 ADC for brain Mets!
Exploratory, small n, real CNS signal.”
See gallery below.
You can also read: TROPION-Breast02: Datopotamab Deruxtecan Shows Intracranial Activity in TNBC With Brain Metastases.
