Parham Habibzadeh, Internal Medicine Resident at UPMC, shared a post on X:
“New paper in Cancer Cell.
Spatial multi-omics of CRC macro- and micrometastases from 19 patients shows liver micrometastases emerge early as a distinct dormant, stem-like state.
They persist after therapy and are surrounded by exhausted immune cells with PD-1/PD-L1 checkpoint signaling.
A 6-gene signature (MicroMetSig) from spatial profiling predicts shorter disease-free survival, higher recurrence risk, and chemotherapy resistance.
Tissue-based markers could complement ctDNA for MRD detection.
What approaches do you see for targeting these hidden micrometastases?”
Title: Spatial multi-omics landscape of colorectal cancer macro- and micrometastases
Authors: Yang Liu, Akshaya S. Jadhav, Yuwen Pan, Jianlong Liao, Isha Khanduri, Yunhe Liu, Riham Katkhuda, Wei Lu, Kyung Serk Cho, Zhimin Tong, Tieling Zhou, Kangyu Lin, Baohua Sun, Mei Jiang, Sharia D. Hernandez, Idania Carolina Lubo Julio, Patrick Brennan, Guangsheng Pei, Kai Yu, Yibo Dai, Tian Chu, Fuduan Peng, Khaja Khan, Saxon Rodriguez, Ling Xia, Youming Guo, Alicia Mejia, Sean W. Barnes, Ou Shi, Shreeya Indulkar, Alaa M. T. Mohamed, Natalie Wall Fowlkes, Timothy Newhook, Yun Shin Chun, Van K. Morris, David Menter, Dadi Jiang, John Paul Shen, Ryan Sun, Jean-Nicolas Vauthey, Ruoyan Li, Humam Kadara, Luisa M. Solis Soto, Scott Kopetz, Linghua Wang, Dipen Maru
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