Noelia Tarazona, Cancer Center Researcher at Massachusetts General Hospital, shared a post on LinkedIn about paper by Francisco Gimeno Valiente et al. published in Nature Genetics:
“So proud of my postdoc, Francisco Gimeno Valiente, at UCL under the supervision of Charles Swanton and Nnenna Kanu for publishing his 2nd paper in NATURE in just three months!.
This groundbreaking work uncovers how genomic and epigenomic drivers converge in lung cancer, introducing a methylation-based dN/dS metric and the novel AllChAT mechanism, providing the first evidence of chromatin-driven autosomal dosage compensation.”
Title: DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution
Authors: Francisco Gimeno-Valiente, Carla Castignani, Elizabeth Larose Cadieux, Nana E. Mensah, Xiaohong Liu, Kezhong Chen, Olga Chervova, Takahiro Karasaki, Clare E. Weeden, Corentin Richard, Siqi Lai, Carlos Martínez-Ruiz, Emilia L. Lim, Alexander M. Frankell, Thomas B. K. Watkins, Georgia Stavrou, Ieva Usaite, Wei-Ting Lu, Daniele Marinelli, Sadegh Saghafinia, Gareth A. Wilson, Pawan Dhami, Heli Vaikkinen, Jonathan Steif, Selvaraju Veeriah, Robert E. Hynds, Martin Hirst, Crispin Hiley, Andrew Feber, Özgen Deniz, Mariam Jamal-Hanjani, Nicholas McGranahan, TRACERx Consortium, Stephan Beck, Jonas Demeulemeester, Miljana Tanić, Charles Swanton, Peter Van Loo, Nnennaya Kanu
You can read the Full Article in Nature Genetics.
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