Nelson Dusetti, Research Director at the Cancer Research Center of Marseille (CRCM), Head of the Translational Research and Innovative Therapies Department, shared on LinkedIn:
“Delighted to see this work published in the journal of Clinical Oncology (JCO Journals).
Congratulations to Rémy Nicolle, Jakob Nikolas Kather and Jerome Cros for leading this study, and to all co-authors for this outstanding collaborative effort.
This study shows that routine H&E slides contain clinically meaningful information that can help predict which patients are more likely to benefit from adjuvant mFOLFIRINOX or gemcitabine after pancreatic cancer surgery.
It is another important step toward treatment selection based on tumor biology, rather than relying only on clinical criteria.
I am particularly happy that our team contributed to this work.
For many years, we have been developing transcriptomic predictors of chemotherapy response in pancreatic cancer.
Seeing complementary AI-based pathology approaches converge toward the same objective reinforces the idea that integrating multiple layers of biological information will be essential to truly personalize treatment for our patients.
This is exactly what translational research should achieve: bringing discoveries from the laboratory into tools that can support clinical decision-making and improve patient care.
Congratulations again to everyone involved, and thank you to the patients, clinicians, pathologists and researchers who made this work possible.”
Tiitle: Developing a Histology-Based Artificial Intelligence Biomarker to Predict Adjuvant Chemotherapy Benefit in Pancreatic Cancer
Authors: Audrey Beaufils, Julien De Martino, Xiaofeng Jiang, Théau Blanchard, Nicolas Fraunhoffer, Diana Mendes, Camille Pignolet, Taib Bourega, Asier Rabasco Meneghetti, Srividhya Sainath, Miguel Albuquerque, Nathalie Colnot, Matthieu Tihy, Anthony Turpin, Meher Ben Abdelghani, Alice Wei, Emmanuel Mitry, Thierry Lecomte, James Biagi, Pascal Artru, Ludovic Evesque, Aurélien Lambert, Daniel J. Renouf, Marjorie Mauduit, Nelson J. Dusetti, Pascal Hammel, Thierry Conroy, Jean-Baptiste Bachet, Louis de Mestier, Vinciane Rebours, Jérôme Cros, Jakob Nikolas Kather, Rémy Nicolle
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