homas Gonatopoulos-Pournatzis and Michael Aregger
Jun 14, 2025, 13:18
CCR Researchers Snipped Over 12,000 Exons Out of the Genomes of Lab-grown Human Cells – NCI Center for Cancer Research
NCI Center for Cancer Research shared a post on LinkedIn:
“SPLICING MATTERS: Using a CRISPR-based gene editing tool, CCR researchers led by Thomas Gonatopoulos-Pournatzis, Ph.D., and Michael Aregger, Ph.D., snipped more than 12,000 exons out of the genomes of lab-grown human cells, one at a time. Then they assessed how well cells grew when they were missing any given exon.
“For the first time, we systematically categorized thousands of different exons to pinpoint which ones may be most interesting for functional follow-up studies, because we see they’re linked to a phenotype that is important for health and disease,” says Dr. Aregger.
Read more about this research Milestone.”
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