Naveen Pemmaraju: Clonal Evolution of Hematopoietic Stem Cells Following Autologous Transplantation
Naveen Pemmaraju, Professor, Department of Leukemia at MD Anderson Cancer Center, shared on X about recent paper by Hidetaka Uryu et al., published in Nature Genetics.
Title: Clonal evolution of hematopoietic stem cells after autologous stem cell transplantation
Authors: Hidetaka Uryu, Koichi Saeki, Hiroshi Haeno, Chiraag Deepak Kapadia, Ken Furudate, Jyoti Nangalia, Michael Spencer Chapman, Li Zhao, Joanne I. Hsu, Chong Zhao, Shujuan Chen, Tomoyuki Tanaka, Zongrui Li, Satoko Ogata, Sarah Hanache, Hui Yang, Courtney DiNardo, Naval Daver, Naveen Pemmaraju, Nitin Jain, Farhad Ravandi, Jianhua Zhang, Xingzhi Song, Erika Thompson, Koichi Takahashi
Read The Full Article at Nature Genetics.
This study explores how cancer chemotherapy, particularly melphalan, affects the genomic integrity and clonal evolution of hematopoietic stem cells. By analyzing over 1,200 stem cell colonies from multiple myeloma patients and healthy donors, researchers found that chemotherapy accelerates clonal aging and reduces clonal diversity—similar to what’s seen in elderly individuals.
The findings suggest that therapy-related myeloid neoplasms often originate from a single dominant clone, highlighting the long-term risks of chemotherapy on normal blood cell development.
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