Robert Orlowski, Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared on X:
“Myeloma Paper of the Day:
The EF1α promoter of cilta-cel drives a highly effective GZMK+ transcriptional program marked by EOMES expression and motif accessibility, but not exhaustion profile supporting both persistence and effector function.”
Title: The EF1α promoter of cilta-cel drives a highly effective GZMK+ transcriptional program
Authors: Kevin Herrera, Sneha Mitra, Yuqing Sun, Kimberly Lucero, Kristin A. Singh, Kevin Chen, Meril Takizawa, Gunjan L. Shah, Sergio Giralt, Jae H. Park, Saad Z. Usmani, Ronan Chaligne, Elisa de Stanchina, Sham Mailankody, Christina S. Leslie, Karlo Perica
You can read the full article on Nature Communications.
You can find other articles featuring Robert Orlowski on OncoDaily.
