The Mark Foundation for Cancer Research shared on X:
“New in Cancer Discovery: Emerging Leader Awardee Liron Bar-Peled lays out a promising new strategy to fight cancer-causing protein fusions using ‘molecular staples.’
The approach relies on Molecular COUPLrs, small molecules bearing two cysteine-reactive warheads that couple proteins together.
When tested on drug-resistant lung cancer cells, the molecules broke down the proteins without triggering resistance.
Even better?
The team built out a platform to uncover targets that has already identified 171 protein classes and showed that existing FDA-approved drugs can be converted into COUPLrs that degrade their targets.”
Title: Systematic Targeting of Protein Complexes with Molecular COUPLrs
Authors: Diane Yang, Stefan Andrew Harry, Harrison Byron Chong, Neha Khandelwal, Edwin Zhang, Natalie Shannon Nordenfelt, Nicholas Chen, Christine Lee, Stefan T. Kaluziak, Elizabeth M. Codd, Samay Trivedi, Magdy Gohar, Giovan McKnight, Dawn R. Mitchell, Maolin Ge, Chengzhuo Gao, Zavontae Holmes, Wenxin Yang, Abigail Elizabeth Smith, Alexander Daniel Carlin, Matthew J. Lazarov, Sufian Moawiyah Ibrahim, Mariko Takahashi, Siwen Zhang, Herman Xin Yang Leong, Hector Martinez Luna, Reilly Stevens, Paul Strickland Mullin, Anastasia Ignashkina, Zander Chearavanont, Kim Emonds, George Popoola, Idris A. Barakat, Maristela L. Onozato, Mohammed Mahamdeh, Toshio Fujino, Jan Gerhartz, Emily E. Ackerman, Huan Yee Koh, Vivek Naranbhai, Hyuk-Soo Seo, Sirano Dhe-Paganon, Zhen-Yu Jim Sun, Gregory J. Heffron, Aaron N. Hata, Roy Jason Soberman, Radoslaw P. Nowak, Christopher J. Ott, Brian B. Liau, A. John Iafrate, Liron Bar-Peled
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