Mario Balsa, Medical Oncologist at Hospital Clínic de Barcelona, shared on X:
“Brilliant discussion by Teresa Amaral at ESMO26 on the evolving post-PD-1 melanoma landscape.
Three very different strategies, remarkably similar signals:
- EV + pembro: ORR 32%
- HER3-DXd: ORR 21%
- FS222: ORR 36%
But the real message: ORR 30% is no longer enough! We need smarter trial populations, earlier referral, meaningful biomarkers and better representation of acral/mucosal melanoma.”

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INTerpath-001 Trial: Personalized mRNA Cancer Vaccine in High-Risk Melanoma
