Maria Hafez, Assistant Professor at St. Luke’s University Health Network, shared on X:
“Day 3 ESMO26 take-homes from Mafalda Oliveira, early HR+/HER2− BC:
- Stage carefully, clip nodes before therapy
- Surgery + genomic score: standard for cT1-2 cN0-1
- Ki67 after 2–4 wk ET adds info
- Young women: the ET given matters as much as biology
- ET-sensitive tumors rarely reach pCR with chemo, even if clinically high risk.
Can CDK4/6i + ET fill the gap? NoLEEta is asking.
Survival, not pCR, will decide.”

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