Liang Cheng, President of International Society of Urological Pathology, Vice Chair for Translational Research at the Warren Alpert Medical School of Brown University, shared on LinkedIn:
“What’s Genomic Drivers of Brain Metastases in Lung Cancer?
I am delighted to share our article published in Neuro Oncology Advances by Dr.Wang and her colleagues Dr.Liu, Benedito A. Carneiro, Abbas Abbas, Matthew Hadfield.
Brain metastases remain one of the most devastating complications of advanced non-small cell lung cancer (NSCLC), affecting up to half of patients during the course of their disease and significantly compromising both survival and quality of life. In this comprehensive systematic review and meta-analysis of 19 studies involving 3,028 patients, we provide an updated synthesis of the genomic landscape driving brain metastases and its implications for precision oncology.
We identified TP53 mutations (50%), PD-L1 overexpression (49%), and high tumor mutational burden (30%) as the most prevalent molecular alterations associated with brain metastases. Additional clinically actionable but less frequent alterations included ERBB2, BRAF, NTRK, PIK3CA, STK11, and KEAP1, highlighting the remarkable molecular heterogeneity of metastatic NSCLC and the expanding opportunities for targeted therapies and immunotherapy.
Importantly, our study demonstrates substantial genomic discordance between primary lung tumors and matched brain metastases, underscoring the importance of site-specific molecular profiling to guide individualized treatment decisions. The authors also review emerging targeted therapies, immunotherapeutic strategies, and ongoing clinical trials, providing a timely roadmap for integrating biomarker-driven precision medicine into the management of patients with NSCLC and brain metastases. This outstanding review will serve as a valuable resource for oncologists, pathologists, translational researchers, and neuroscientists seeking to improve outcomes for patients with this challenging disease.”
Title: Genomic drivers of brain metastases in lung cancer
Authors: Ting Wang, Hang Xing, Lei Huang, Hao Zhuang, Jianguo Zhang, Hong Ge, Bo Zhang, Yue Cao, Yining Zhai, Xiaoli Zheng, Shanshan Bu, Abbas E. Abbas, Matthew Hadfield, Benedito A. Carneiro, Liang Cheng, Yifei Liu
Read the full article.
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