Farastuk Bozorgmehr, Head of Clinical Trials Unit Thoracic Oncology at Thoraxklinik Heidelberg, shared a post on LinkedIn:
“Today is a special day for me: our TREASURE trial has been published in JAMA Oncology.
TREASURE started with a compelling clinical question: could consolidative thoracic radiotherapy improve outcomes when added to atezolizumab maintenance in patients with extensive-stage small cell lung cancer?
The answer was not the one we had hoped for.
In our randomized phase 2 trial, the combination did not improve survival and was associated with significantly severe toxicity, including fatal adverse events. Recruitment was therefore stopped prematurely.
But negative results matter. Our in-depth safety analyses point to persistent lymphocyte depletion after thoracic radiotherapy as a potential contributor to the observed toxicity and infections. These findings raise important questions about patient selection and the biological consequences of combining radiotherapy and immunotherapy.
I am deeply grateful to all patients and their families who participated in this trial, and to the investigators and study teams at 20 centers in Germany and Austria.
TREASURE was an investigator-initiated, truly interdisciplinary effort developed within the AIO, sponsored by the IKF – The Frankfurt Institute of Clinical Cancer Research, and coordinated from Thoraxklinik Heidelberg gGmbH.
Bringing this study from an idea to a randomized multicenter trial, and now to publication in JAMA Oncology, would not have been possible without an exceptional team.
A huge thank you to everyone who contributed along the way.”
Title: Consolidative Thoracic Radiotherapy With Atezolizumab Maintenance in Extensive-Stage Small Cell Lung Cancer – The Phase 2 TREASURE Randomized Clinical Trial (AIO-TRK-0320)
Authors: Farastuk Bozorgmehr, Inn Chung, Rouven Behnisch, Fabian Weykamp, Sebastian Adeberg, Tobias Overbeck, Rami El Shafie, Nadia Maguire, Stefan A. Koerber, Eva Lotte Buchmeier, Michaela Hammer-Hellmig, Thomas Gauler, Christoph Pöttgen, Martin Wermke, Esther G. C. Troost, Konrad Kokowski, Barbara Röper, Anke Reinacher-Schick, Nicole-Sophie Consdorf, Matthias Ulmer, Arndt-Christian Müller, Thomas Wehler, Silla Hey-Koch, Jürgen Alt, Marcus Stockinger, Jonas Kuon, Marc Bischof, Bernd Lamprecht, Hans Geinitz, Christian Lerchenmüller, Jan Kriz, Markus Rauter, Wolfgang Raunik, Bernd Schmidt, Andrej Stupavsky, Cornelia Kropf-Sanchen, Gerlinde Schmidtke-Schrezenmeier, Thomas Wiegel, Amanda Tufman, Farkhad Manapov, Marie Merling, Claus Peter Heussel, Markus Polke, Martin Reck, Salah-Eddin Al-Batran, Michael Thomas, Petros Christopoulos, Stefan Rieken
Read the Full Article.
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