Science

Elinzanetant Eases Hot Flashes in Breast Cancer Endocrine Therapy – The Babak Lab

The Babak Lab/LinkedIn

Jul 14, 2025, 15:26

Elinzanetant Eases Hot Flashes in Breast Cancer Endocrine Therapy – The Babak Lab

The Babak Lab shared a post on LinkedIn:

“Clinical Mondays: Elinzanetant Eases Hot Flashes in Breast Cancer Endocrine Therapy

A phase III trial published in NEJM (June 2025) reports that elinzanetant, a nonhormonal NK-1/NK-3 antagonist, significantly reduces vasomotor symptoms in women on endocrine therapy for hormone receptor–positive breast cancer.

Study Focus:
Assess the safety and efficacy of once-daily elinzanetant (120 mg) vs placebo in reducing moderate-to-severe hot flashes during 52 weeks of endocrine therapy.

Experimental Highlights:

Randomized, double-blind, placebo-controlled OASIS‑4 with 474 women aged 18–70
Elinzanetant arm: 316 participants; placebo then crossover: 158
Baseline average: 11.4 moderate-to-severe vasomotor episodes/day
Reduction at Week 4: −6.5 vs −3.0 episodes (p < 0.001)
Reduction at Week 12: −7.8 vs −4.2 (p < 0.001)
≥50% symptom reduction in 74.3% vs 35.8% at 12 weeks

Key Findings:

Major reduction in hot flash frequency
Significant improvement in sleep and quality of life
Well-tolerated; most AEs were mild (headache, fatigue, somnolence)
Serious AEs rare (2.5% vs 0.6%), liver enzyme changes reversible

Conclusion:

Elinzanetant offers a promising nonhormonal option to manage vasomotor symptoms caused by endocrine therapy, potentially improving adherence and quality of life for breast cancer survivors.”

Title: Elinzanetant Eases Hot Flashes in Breast Cancer Endocrine Therapy

Authors: Fatima Cardoso, Susanne Parke, Donal J. Brennan, Paula Briggs, Gilbert Donders, Nick Panay, F.R.C.O.G., Nazanin Haseli-Mashhadi, Michael Block, Cecilia Caetano, Maja Francuski, Claudia Haberland, Kaisa Laapas, Christian Seitz and Lineke Zuurman

Read the Full Article.

Elinzanetant case study

More posts featuring The Babak Lab on OncoDaily.

Breast Cancer Endocrine Therapy cancer Cecilia Caetano Christian Seitz Claudia Haberland Donal J. Brennan Elinzanetant Fatima Cardoso Gilbert Donders Kaisa Laapas Lineke Zuurman Maja Francuski Michael Block Nazanin Haseli Mashhadi Nick Panay OncoDaily Oncology Paula Briggs Susanne Parke The Babak Lab

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