Francisco Esteva: New Study Shows that BSO Markedly Reduces Cancer Risk in BRCA1/2 Carriers
Francisco Esteva, Director of the Breast Cancer Translational Research at Northwell Health and Chief of the Division of Hematology and Medical Oncology at Lenox Hill Hospital, shared a post on LinkedIn about a paper by Hend Hassan et al. published in The Lancet Oncology:
“New study shows removal of the ovaries and fallopian tubes markedly reduces cancer risk in BRCA1/2 carriers.
In women with pathogenic BRCA1 and BRCA2 variants who previously had breast cancer, bilateral salpingo-oophorectomy – BSO significantly cuts all-cause mortality by 48% and breast cancer-specific mortality, with reductions of 38% in BRCA1 and 52% in BRCA2 carriers. BSO also decreases the risk of a second non-breast cancer by 41% without increasing the risk of major diseases, showcasing a safe profile.
This research is pivotal given the variation in BSO uptake linked to ethnicity and socioeconomic factors, needing targeted educational and healthcare interventions to bridge disparities. With a moderate follow-up period and potential confounding, further studies are necessary, particularly concerning hormone replacement post-BSO.”
Title: Long-term health outcomes of bilateral salpingo-oophorectomy in BRCA1 and BRCA2 pathogenic variant carriers with personal history of breast cancer: a retrospective cohort study using linked electronic health records
Authors: Hend Hassan, Isaac Allen, Tameera Rahman, Sophie Allen, Craig Knott, Catherine Huntley, Lucy Loong, Alice Garrett, Yvonne Walburga, Eva Morris, Steven Hardy, Bethany Torr, Fiona McRonald, Sally Vernon, Margreet Lüchtenborg, Joanna Pethick, Francesco Santaniello, Shilpi Goel, Diana Eccles, Clare Turnbull, Marc Tischkowitz, Paul Pharoah, Antonis Antoniou.
You can read the Full Article in The Lancet Oncology.
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