Benjamin Ebert, President and CEO at Dana-Farber Cancer Institute, shared on LinkedIn:
“Why do some people who never smoked develop lung cancer? New research from Dana-Farber Cancer Institute demonstrates that this is partly due to genetically inherited risk.
Jaclyn LoPiccolo, and her colleagues found that people born with a rare mutation in the EGFR gene have a greater than 60-fold increased risk of developing lung cancer among people who had never smoked. This finding holds the potential to develop personalized screening for individuals with this inherited risk, enabling early detection and improved outcomes.
These findings deepen our understanding of how genetics may influence cancer risk and can help us learn how to identify people who could benefit from earlier, more personalized screening.
This research was enabled by a powerful collaboration with 23andMe Research Institute. I am proud of the Dana-Farber investigators behind this work. This is a discovery that holds the potential to save many lives.”
Title: Germline EGFR T790M Mutation and Lung Cancer Risk
Authors: Jaclyn LoPiccolo, Steven Micheletti, Jing Shi, Wei Wang, Shubham Saini, Keng-Han Lin, Wanwan Xu, Pierre Fontanillas, 23andMe Research Team, Diane R. Koeller, Helen Yatzus, Victoria G. Williamson, Jose A. Avila, Raphael B. Liautaud, Noah D. Fields, Allison Harper, Virginia Kotait, Ericka Izzo, Andrew Ciupek, Courtney A. Granville, Ryan L. Collins, Judy E. Garber, David C. Christiani, Stella Aslibekyan, Julie M. Granka, Alexander Gusev, Pasi A. Jänne.
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